Currently, approximately three-to-five percent (3-5%) of the T-cells Infused into a patient enter the Tumor Micro-Environment from the blood vasculature. This means 95% of the cells generated are wasted or, worse, rampage through the body causing side effects.

TZ 102 Enables Tumor Infiltrating Lymphocytes (TILs) to ‘home’, that is, to be directed to the tumor micro-environment more effectively from the blood vasculature by improving Tumor Infiltrating Lymphocyte cell rolling, tethering on the endothelial cells of the blood vessels and promoting their extravasation through the blood-vessel walls, enabling their transmigration into the tumor micro-environment. This results in 300-500% more T-cells reaching the tumor-micro-environment

Fucosylated T-Cells ‘Home’ to the Tumor Micro-Environment More Effectively through Improved T-cell Rolling, Tethering, Extravasation

In addition to enabling 300-500% more T-cells to enter the tumor-micro-environment from the blood stream, TZ 102 increases T-cell binding to tumors and increases T-Cell intra-tumor penetration. TZ 102 also increases the number of T-cells expressing FASL and intracellular Granzyme B and Perforin, all consistent with enhanced T-cell cytoxicity for increased tumor killing.

Fucosylated TZ 102 TILs versus CAR-T, TCR-Ts and TIL Cells

Unfucosylated CAR-T, TCR-T, TIL Cells:

Approximately 3-5 Percent of the T-cells Typically Enter the Tumor Micro-Environment from the Blood Stream whereupon CAR, TCR enable T-cells to better target the Cancer Cells

Why is TZ 102 + TIL therapy so important

    • TIL cell approach enables improved targeting without genetic engineering
    • 300-500% more T-cells Entering the Tumor Micro-Environment from the Blood Stream
    • Increased T-cell Binding to Tumors
    • Increased T-cell Killing Machinery: FASL, Granzyme B, Perforin
    • Fucosylation Promotes T-cell Intra-Tumor Penetration & Increased Tumor Killing
Targazyme’s Propr ietary Manufacturing Process can be used with CAR-T,TCR-T and other TIL productunder a licensing agr eement